Autophagy inhibition upregulates CD4⁺ tumor infiltrating lymphocyte expression via miR-155 regulation and TRAIL activation.

ABSTRACT: Chemoresistance is a major challenge in lung cancer treatment. Recent findings have revealed that autophagic mechanism contributes significantly to immunosuppressive related chemoresistance. For that reason, targeting autophagy-related immunosuppression is an important approach to reverse tumor drug resistance. In this study, we report for the first time that autophagy inhibition triggers upregulation of CD4⁺, Foxp3⁺ tumor infiltrating lymphocytes in late metastatic lung cancer tissues. Furthermore, autophagy blockage induces chemosensitization to carboplatin, immune activation and cell cycle arrest. This induction correlated with reduction in expression of drug resistance genes MDR1, MRP1, ABCG2 and ABCC2 along with decreased expression of PD-L1 which is associated w

SUBMITTER: Zarogoulidis P 

PROVIDER: S-EPMC5423126 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature