MRNA expression profiles of colorectal liver metastases as a novel biomarker for early recurrence after partial hepatectomy.

ABSTRACT:

Background

Identification of specific risk groups for recurrence after surgery for isolated colorectal liver metastases (CRLM) remains challenging due to the heterogeneity of the disease. Classical clinicopathologic parameters have limited prognostic value. The aim of this study was to identify a gene expression signature measured in CRLM discriminating early from late recurrence after partial hepatectomy.

Methods

CRLM from two patient groups were collected: I) with recurrent disease ≤12 months after surgery (N = 33), and II) without recurrences and disease free for ≥36 months (N = 30). The patients were clinically homogeneous; all had a low clinical risk score (0-2) and did not receive (neo-) adjuvant chemotherapy. Total RNA was hybridised to Illumina arrays, and processed

SUBMITTER: van der Stok EP 

PROVIDER: S-EPMC5423127 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature