Unbiased identification of substrates of protein tyrosine phosphatase ptp-3 in C. elegans.

ABSTRACT: The leukocyte antigen related (LAR) family of receptor-like protein tyrosine phosphatases has three members in humans - PTPRF, PTPRD and PTPRS - that have been implicated in diverse processes including embryonic development, inhibition of cell growth and axonal guidance. Mutations in the LAR family are associated with developmental defects such as cleft palate as well as various cancers including breast, neck, lung, colon and brain. Although this family of tyrosine phosphatases is important for many developmental processes, little is known of their substrates. This is partially due to functional redundancy within the LAR family, as deletion of a single gene in the LAR family does not have an appreciable phenotype, but a dual knockout is embryonically lethal in mouse models. To circumvent t

SUBMITTER: Mitchell CJ 

PROVIDER: S-EPMC5423164 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature