A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer.

ABSTRACT: Increasing interest has been devoted in recent years to the understanding of alternative splicing in cancer. In this study, we performed a genome-wide analysis to identify cancer-associated splice variants in non-small cell lung cancer. We discovered and validated novel differences in the splicing of genes known to be relevant to lung cancer biology, such as NFIB, ENAH or SPAG9. Gene enrichment analyses revealed an important contribution of alternative splicing to cancer-related molecular functions, especially those involved in cytoskeletal dynamics. Interestingly, a substantial fraction of the altered genes found in our analysis were targets of the protein quaking (QKI), pointing to this factor as one of the most relevant regulators of alternative splicing in non-small cell lung cancer. W

SUBMITTER: de Miguel FJ 

PROVIDER: S-EPMC5423218 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature