Continuous spike-waves during slow-wave sleep in a mouse model of focal cortical dysplasia.

ABSTRACT:

Objective

To examine if mice with focal cortical dysplasia (FCD) develop spontaneous epileptic seizures and, if so, determine the key electroencephalography (EEG) features.

Methods

Unilateral single freeze lesions to the S1 region (SFLS1R) were made in postnatal day 0-1 pups to induce a neocortical microgyrus in the right cortical hemisphere. Continuous 24-h recordings with intracranial EEG electrodes and behavioral tests were performed in adult SFLS1R and sham-control mice to assess neurologic status.

Results

A high percentage of adult SFLS1R animals (89%, 40/45) exhibited at least one or more spontaneous nonconvulsive seizure events over the course of 24 h. Of these animals, 60% (27/45) presented with a chronic seizure state that was persistent throughout the record

SUBMITTER: Sun QQ 

PROVIDER: S-EPMC5423360 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature