H2B monoubiquitination: t'ub or not t'ub for inducible enhancers.

ABSTRACT: Recently, we reported the unexpected finding that the monoubiquitination of histone H2B (H2Bub1) regulates inducible enhancers. Here, we propose a conceptual framework to reconcile the apparently discrepant roles of H2Bub1 in transcription initiation and elongation, and we discuss how H2Bub1 could regulate cellular processes linked to non-coding transcription.

SUBMITTER: Segala G 

PROVIDER: S-EPMC5423472 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature