Feasibility of Applying Helper-Dependent Adenoviral Vectors for Cancer Immunotherapy.

ABSTRACT: Adenoviruses (Ads) infect a broad range of tissue types, and derived vectors have been extensively used for gene therapy. Helper-dependent Ad vectors (HDAds), devoid of viral coding sequences, allow for insertion of large or multiple transgenes in a single vector and have been preclinically used for the study of genetic disorders. However, the clinical application of Ad vectors including HDAds for genetic disorders has been hampered by an acute toxic response. This characteristic, while disadvantageous for gene replacement therapy, could be strategically advantageous for the activation of an immune response if HDAds were used as an adjunct treatment in cancer. Cancer treatments including immunotherapy are frequently limited by the inhibitory environment produced by both tumors and their st

SUBMITTER: Farzad LM 

PROVIDER: S-EPMC5423480 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature