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PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.

ABSTRACT: We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.

SUBMITTER: Fuchs A

PROVIDER: S-EPMC5423499 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.

Fuchs Alisa A Torroba Marcos M Kinkley Sarah S

Transcription 20170119 2

We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing. ...[more]

PMID: 28102760

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