Identifying biologically relevant putative mechanisms in a given phenotype comparison.

ABSTRACT: A major challenge in life science research is understanding the mechanism involved in a given phenotype. The ability to identify the correct mechanisms is needed in order to understand fundamental and very important phenomena such as mechanisms of disease, immune systems responses to various challenges, and mechanisms of drug action. The current data analysis methods focus on the identification of the differentially expressed (DE) genes using their fold change and/or p-values. Major shortcomings of this approach are that: i) it does not consider the interactions between genes; ii) its results are sensitive to the selection of the threshold(s) used, and iii) the set of genes produced by this approach is not always conducive to formulating mechanistic hypotheses. Here we present a method tha

SUBMITTER: Hanoudi S 

PROVIDER: S-EPMC5423614 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature