Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses.

ABSTRACT: Cell entry of many enveloped viruses occurs by engagement with cellular receptors, followed by internalization into endocytic compartments and pH-induced membrane fusion. A previously unnoticed step of receptor switching was found to be critical during cell entry of two devastating human pathogens: Ebola and Lassa viruses. Our recent studies revealed the functional role of receptor switching to LAMP1 for triggering membrane fusion by Lassa virus and showed the involvement of conserved histidines in this switching, suggesting that other viruses from this family may also switch to LAMP1. However, when we investigated viruses that are genetically close to Lassa virus, we discovered that they cannot bind LAMP1. A crystal structure of the receptor-binding module from Morogoro virus revealed str

SUBMITTER: Israeli H 

PROVIDER: S-EPMC5423696 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature