Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.

ABSTRACT:

Background

Animal studies have increasingly highlighted the role of macrophages in the development of delayed gastric emptying. However, their role in the pathophysiology of human gastroparesis is unclear. Our aim was to determine changes in macrophages and other cell types in the gastric antrum muscularis propria of patients with diabetic and idiopathic gastroparesis.

Methods

Full thickness gastric antrum biopsies were obtained from patients enrolled in the Gastroparesis Clinical Research Consortium (11 diabetic, 6 idiopathic) and 5 controls. Immunolabeling and quantitative assessment was done for interstitial cells of Cajal (ICC) (Kit), enteric nerves protein gene product 9.5, neuronal nitric oxide synthase, vasoactive intestinal peptide, substance P, tyrosine hydroxylase)

SUBMITTER: Grover M 

PROVIDER: S-EPMC5423829 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature