Adverse and Hypersensitivity Reactions to Prescription Nonsteroidal Anti-Inflammatory Agents in a Large Health Care System.

ABSTRACT:

Background

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used medications in the United States. NSAID use can be limited by adverse drug reactions (ADRs), including hypersensitivity reactions (HSRs).

Objective

We aimed to use electronic health record data to determine the incidence and predictors of HSRs to prescription NSAIDs.

Methods

We performed a retrospective cohort study of all adult outpatients in a large health care system prescribed diclofenac, indomethacin, nabumetone, or piroxicam between January 1, 2004, and September 30, 2012. The primary outcome was an ADR or HSR attributed to the prescribed NSAID within 1 year of prescription, determined from a longitudinal allergy database. We used natural language processing to classify k

SUBMITTER: Blumenthal KG 

PROVIDER: S-EPMC5423842 | biostudies-literature | 2017 May - Jun

REPOSITORIES: biostudies-literature