The association of chronic kidney disease and microalbuminuria with heart failure with preserved vs. reduced ejection fraction.

ABSTRACT:

Aims

Chronic kidney disease (CKD) and microalbuminuria are associated with incident heart failure (HF), but their relative contributions to HF with preserved vs. reduced EF (HFpEF and HFrEF) are unknown. We sought to evaluate the associations of CKD and microalbuminuria with incident HF subtypes in the community-based Framingham Heart Study (FHS).

Methods and results

We defined CKD as glomerular filtration rate <60 mL/min/1.73 m² , and microalbuminuria as a urine albumin to creatinine ratio (UACR) ≥17 mg/g in men and ≥25 mg/g in women. We observed 754 HF events (324 HFpEF/326 HFrEF/104 unclassified) among 9889 FHS participants with serum creatinine measured (follow-up 13 ± 4 years). In Cox models adjusted for clinical risk factors, CKD (prevalence = 9%) was associ

SUBMITTER: Nayor M 

PROVIDER: S-EPMC5423843 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature