Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years.

ABSTRACT:

Purpose

The aims of the study were to develop a population pharmacokinetic model of orally administered brivaracetam in paediatric patients and to provide dosing suggestions.

Methods

Analysis included 600 brivaracetam plasma concentrations from a phase 2a study (NCT00422422; N01263) in 96 paediatric patients with epilepsy aged 1 month to 16 years, taking one to three concomitant antiepileptic drugs (AEDs). Pharmacokinetic analysis was performed using non-linear mixed effects modelling, and a stepwise covariate search was used to determine factors influencing brivaracetam clearance. Simulations were performed to investigate dosing regimens.

Results

The final model consisted of first-order absorption, single compartment distribution and first-order elimination component

SUBMITTER: Schoemaker R 

PROVIDER: S-EPMC5423986 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature