Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population.

ABSTRACT:

Background

Children with a diagnosis of attention-deficit hyperactivity disorder ADHD) have lower cognitive ability and are at risk of adverse educational outcomes; ADHD genetic risks have been found to predict childhood cognitive ability and other neurodevelopmental traits in the general population; thus genetic risks might plausibly also contribute to cognitive ability later in development and to educational underachievement.

Methods

We generated ADHD polygenic risk scores in the Avon Longitudinal Study of Parents and Children participants (maximum N : 6928 children and 7280 mothers) based on the results of a discovery clinical sample, a genome-wide association study of 727 cases with ADHD diagnosis and 5081 controls. We tested if ADHD polygenic risk scores were associated

SUBMITTER: Stergiakouli E 

PROVIDER: S-EPMC5424076 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature