Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development.

ABSTRACT: Ran-binding protein family member, RanBP9 has been reported in various basic cellular mechanisms and neuropathological conditions including schizophrenia. Previous studies have reported that RanBP9 is highly expressed in the mammalian brain and retina; however, the role of RanBP9 in retinal development is largely unknown. Here, we present the novel and regulatory roles of RanBP9 in retinal development of a vertebrate animal model, zebrafish. Zebrafish embryos exhibited abundant expression of ranbp9 in developing brain tissues as well as in the developing retina. Yeast two-hybrid screening demonstrated the interaction of RanBP9 with Mind bomb, a component of Notch signaling involved in both neurogenesis and neural disease autism. The interaction is further substantiated by co-localiz

SUBMITTER: Yoo KW 

PROVIDER: S-EPMC5424273 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature