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Selecting reactions and reactants using a switchable rotaxane organocatalyst with two different active sites.

ABSTRACT: The activation mode of a rotaxane-based organocatalyst with both secondary amine and squaramide catalytic units can be switched with acid or base. The macrocycle blocks whichever of the catalytic sites it is positioned over. The switchable rotaxane catalyst generates different products from a mixture of three building blocks according to the location of the macrocyclic ring in the rotaxane.

SUBMITTER: Beswick J

PROVIDER: S-EPMC5424444 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Selecting reactions and reactants using a switchable rotaxane organocatalyst with two different active sites.

Beswick Jack J Blanco Victor V De Bo Guillaume G Leigh David A DA Lewandowska Urszula U Lewandowski Bartosz B Mishiro Kenji K

Chemical science 20141113 1

The activation mode of a rotaxane-based organocatalyst with both secondary amine and squaramide catalytic units can be switched with acid or base. The macrocycle blocks whichever of the catalytic sites it is positioned over. The switchable rotaxane catalyst generates different products from a mixture of three building blocks according to the location of the macrocyclic ring in the rotaxane. ...[more]

PMID: 28553462

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