Gene expression based evidence of innate immune response activation in the epithelium with oral lichen planus.

ABSTRACT:

Objective

Oral lichen planus (OLP) is a disease of the oral mucosa of unknown cause producing lesions with an intense band-like inflammatory infiltrate of T cells to the subepithelium and keratinocyte cell death. We performed gene expression analysis of the oral epithelium of lesions in subjects with OLP and its sister disease, oral lichenoid reaction (OLR), in order to better understand the role of the keratinocytes in these diseases.

Design

Fourteen patients with OLP or OLR were included in the study, along with a control group of 23 subjects with a variety of oral diseases and a normal group of 17 subjects with no clinically visible mucosal abnormalities. Various proteins have been associated with OLP, based on detection of secreted proteins or changes in RNA levels in ti

SUBMITTER: Adami GR 

PROVIDER: S-EPMC5424530 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature