Atomically precise organomimetic cluster nanomolecules assembled via perfluoroaryl-thiol S_NAr chemistry.

ABSTRACT: The majority of biomolecules are intrinsically atomically precise, an important characteristic that enables rational engineering of their recognition and binding properties. However, imparting a similar precision to hybrid nanoparticles has been challenging because of the inherent limitations of existing chemical methods and building blocks. Here we report a new approach to form atomically precise and highly tunable hybrid nanomolecules with well-defined three-dimensionality. Perfunctionalization of atomically precise clusters with pentafluoroaryl-terminated linkers produces size-tunable rigid cluster nanomolecules. These species are amenable to facile modification with a variety of thiol-containing molecules and macromolecules. Assembly proceeds at room temperature within hours under mild

SUBMITTER: Qian EA 

PROVIDER: S-EPMC5424550 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature