Identifying brain nociceptive information transmission in patients with chronic somatic pain.

ABSTRACT:

Introduction

Recent advances regarding mechanisms of chronic pain emphasize the role of corticolimbic circuitry in predicting risk for chronic pain, independently from site of injury-related parameters. These results compel revisiting the role of peripheral nociceptive signaling in chronic pain. We address this issue by examining what brain circuitry transmit information regarding the intensity of chronic pain and how this information may be related to a common co-morbidity, depression.

Methods

Resting state functional MRI was used in a large group of chronic pain patients (n=40 chronic back pain, CBP, and n=44 osteoarthritis, OA patients), and in comparison to healthy subjects (n=88). We used a graph theoretical measure, degree count, to investigate voxel-wise information s

SUBMITTER: Davis DA 

PROVIDER: S-EPMC5424698 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature