Expression profiling of colorectal cancer cells reveals inhibition of DNA replication licensing by extracellular calcium.

ABSTRACT: Colorectal cancer is one of the most common cancers in industrialised societies. Epidemiological studies, animal experiments, and randomized clinical trials have shown that dietary factors can influence all stages of colorectal carcinogenesis, from initiation through promotion to progression. Calcium is one of the factors with a chemoprophylactic effect in colorectal cancer. The aim of this study was to understand the molecular mechanisms of the anti-tumorigenic effects of extracellular calcium ([Ca²⁺]_o) in colon cancer cells. Gene expression microarray analysis of colon cancer cells treated for 1, 4, and 24h with 2mM [Ca²⁺]_o identified significant changes in expression of 1571 probe sets (ANOVA, p<10^-5). The main biological processes

SUBMITTER: Aggarwal A 

PROVIDER: S-EPMC5424886 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature