Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption.

ABSTRACT: Inflammatory bone resorption mediated by osteoclasts is a major cause of morbidity and disability in many inflammatory disorders, including rheumatoid arthritis (RA). The mechanisms that regulate osteoclastogenesis and bone resorption in inflammatory settings are complex and have not been well elucidated. In this study, we identify the immunoregulator differentially expressed in FDCP 6 homolog (Def6) as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions. Def6 deficiency in Def6^-/- mice enhanced the sensitivity of osteoclast precursors to the physiological osteoclastogenic inducer receptor activator for NF-κB ligand, and Def6^-/- osteoclasts formed actin rings. Furthermore, Def6 deficiency markedly increased TNF-α-induced

SUBMITTER: Binder N 

PROVIDER: S-EPMC5425156 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature