MiR-27a and miR-449b polymorphisms associated with a risk of idiopathic recurrent pregnancy loss.

ABSTRACT:

Objective

MicroRNAs (miRNAs) regulate gene expression during the peri-implantation period. The purpose of this study was to investigate whether genetic polymorphisms in the four miRNAs associated with fetal or placental development play roles in the development of idiopathic recurrent pregnancy loss (RPL) in Korean females.

Study design

A case-control study involving 225 controls and 387 women with at least two consecutively recurrent pregnancy losses between 1999 and 2012 was performed. The genotypes of the four miRNA polymorphisms, including miR-27a rs895819, miR-423 rs6505162, miR-449b rs10061133, and miR-605 rs2043556, were analyzed by the polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios and 95% confidence intervals were estimated usi

SUBMITTER: Rah H 

PROVIDER: S-EPMC5425187 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature