Myocardial Injury, Obesity, and the Obesity Paradox: The ARIC Study.

ABSTRACT:

Objectives

This study sought to determine whether pre-heart failure (HF) myocardial injury explains the differential mortality after HF across weight categories.

Background

Obesity is a risk factor for HF, but pre-HF obesity is associated with lower mortality after incident HF. High-sensitivity cardiac troponin T (hs-cTnT) is a sensitive marker of myocardial injury, and predicts incident HF and mortality.

Methods

Stratifying 1,279 individuals with incident HF hospitalizations by their pre-HF hs-cTnT levels (< and ≥ 14 ng/l), we examined the association of pre-HF body mass index (BMI) with mortality after incident HF hospitalization in the ARIC (Atherosclerosis Risk In Communities) study.

Results

Mean age at HF was 74 years (53% women, 27% black). Individuals wi

SUBMITTER: Pokharel Y 

PROVIDER: S-EPMC5425302 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature