Neurophysiological capacity in a working memory task differentiates dependent from nondependent heavy drinkers and controls.

ABSTRACT:

Background

Determining the neurobehavioral profiles that differentiate heavy drinkers who are and are not alcohol dependent will inform treatment efforts. Working memory is linked to substance use disorders and can serve as a representation of the demand placed on the neurophysiology associated with cognitive control.

Methods

Behavior and brain activity (via fMRI) were recorded during an N-Back working memory task in controls (CTRL), nondependent heavy drinkers (A-ND) and dependent heavy drinkers (A-D). Typical and novel step-wise analyses examined profiles of working memory load and increasing task demand, respectively.

Results

Performance was significantly decreased in A-D during high working memory load (2-Back), compared to CTRL and A-ND. Analysis of brain activit

SUBMITTER: Wesley MJ 

PROVIDER: S-EPMC5425311 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature