In Vivo Comparison of Tau Radioligands ¹⁸F-THK-5351 and ¹⁸F-THK-5317.

ABSTRACT: This study compared the in vivo imaging characteristics of tau PET ligands ¹⁸F-THK-5351 and ¹⁸F-THK-5317 in the context of Alzheimer disease (AD). Additionally, reference tissue distribution volume ratio (DVR) estimation methods and SUV ratio (SUVR) timing windows were evaluated to determine the optimal strategy for specific binding quantification. Methods: Twenty-eight subjects (mean age ± SD, 71 ± 7 y) underwent either dynamic 90-min ¹⁸F-THK-5317 or ¹⁸F-THK-5351 PET scans. Bland-Altman plots were used to compare the simplified reference tissue method, multilinear reference tissue method (MRTM2), and Logan reference tissue DVR estimates and to assess temporal stability of SUVR windows using cerebellar gray matter as a reference region. In

SUBMITTER: Betthauser TJ 

PROVIDER: S-EPMC5425312 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature