Effects of localized interactions and surface properties on stability of protein-based therapeutics.

ABSTRACT:

Objectives

Protein-based therapeutics garner significant attention because of exquisite specificity and limited side effects and are now being used to accomplish targeted delivery of small-molecule drugs. This review identifies and highlights individual chemical attributes and categorizes how site-specific changes affect protein stability based on published high-resolution molecular analyses.

Key findings

Because it is challenging to determine the mechanisms by which the stability of large, complex molecules is altered and data are sparse, smaller, therapeutic proteins (insulin, erythropoietin, interferons) are examined alongside antibody data. Integrating this large pool of information with the limited available studies on antibodies reveals common mechanisms by which speci

SUBMITTER: Mills BJ 

PROVIDER: S-EPMC5425321 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature