Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.

ABSTRACT: Spatial models of vascularized tissues are widely used in computational physiology. We introduce a software library for composing multiscale, multiphysics models for applications including tumor growth, angiogenesis, osteogenesis, coronary perfusion, and oxygen delivery. Composition of such models is time consuming, with many researchers writing custom software. Recent advances in imaging have produced detailed three-dimensional (3D) datasets of vascularized tissues at the scale of individual cells. To fully exploit such data there is an increasing need for software that allows user-friendly composition of efficient, 3D models of vascularized tissues, and comparison of predictions with in vivo or in vitro experiments and alternative computational formulations. Microvessel Chaste can be use

SUBMITTER: Grogan JA 

PROVIDER: S-EPMC5425404 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature