Mechanosensitive Conformation of Vinculin Regulates Its Binding to MAPK1.

ABSTRACT: Extracellular matrix stiffness sensing by living cells is known to play a major role in a variety of cell mechanobiological processes, such as migration and differentiation. Various membrane and cytoplasmic proteins are involved in transmitting and transducing environmental signals to biochemical cascades. Protein kinases play a key role in regulating the activity of focal adhesion proteins. Recently, an interaction between mitogen-activated protein kinase (MAPK1) and vinculin was experimentally shown to mediate this process. Here, we adopt a molecular modeling approach to further investigate this interaction and its possible regulatory effects. Using a combination of data-driven flexible docking and molecular dynamics simulations guided by previous experimental studies, we predict the str

SUBMITTER: Garakani K 

PROVIDER: S-EPMC5425409 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature