Differing Complex Microbiota Alter Disease Severity of the IL-10^-/- Mouse Model of Inflammatory Bowel Disease.

ABSTRACT: It is estimated that 1.4 million people in the United States suffer from Inflammatory Bowel Disease (IBD), with an overall annual health care cost of more than $1.7 billion. Although the exact etiology of this disease remains unknown, research suggests that it is a multifactorial disease associated with aberrant gastrointestinal microbial populations (dysbiosis). The C57BL/6 and C3H/HeJBir mouse strains with targeted mutations in the IL-10 gene are commonly used models to study IBD. However, anecdotally, disease phenotype can vary in severity from lab to lab. Moreover, studies using germfree and monocolonized mice have suggested that gut microbiota (GM) are critical to disease induction in these models. With recent studies suggesting variation in naturally occurring GM composition and comp

SUBMITTER: Hart ML 

PROVIDER: S-EPMC5425584 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature