Fast Protein Translation Can Promote Co- and Posttranslational Folding of Misfolding-Prone Proteins.

ABSTRACT: Chemical kinetic modeling has previously been used to predict that fast-translating codons can enhance cotranslational protein folding by helping to avoid misfolded intermediates. Consistent with this prediction, protein aggregation in yeast and worms was observed to increase when translation was globally slowed down, possibly due to increased cotranslational misfolding. Observation of similar behavior in molecular simulations would confirm predictions from the simpler chemical kinetic model and provide a molecular perspective on cotranslational folding, misfolding, and the impact of translation speed on these processes. All-atom simulations cannot reach the timescales relevant to protein synthesis, and most conventional structure-based coarse-grained models do not allow for nonnative stru

SUBMITTER: Trovato F 

PROVIDER: S-EPMC5425611 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature