Ontology highlight
ABSTRACT:
SUBMITTER: Hadjimichael C
PROVIDER: S-EPMC5425614 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Stem cell reports 20170406 5
Promyelocytic leukemia protein (PML), the main constituent of PML nuclear bodies, regulates various physiological processes in different cell types. However, little is known about its functions in embryonic stem cells (ESC). Here, we report that PML contributes to ESC self-renewal maintenance by controlling cell-cycle progression and sustaining the expression of crucial pluripotency factors. Transcriptomic analysis and gain- or loss-of-function approaches showed that PML-deficient ESC exhibit mo ...[more]