Responsible Translation of Stem Cell Research: An Assessment of Clinical Trial Registration and Publications.

ABSTRACT: We assessed the extent to which the publication of clinical trial results of innovative cell-based interventions reflects International Society for Stem Cell Research best practice guidelines. We assessed: (1) characteristics and time to publication of completed trials; (2) quality of reported trials; and (3) results of published trials. We identified and analyzed publications from 1,052 novel stem cell clinical trials: 179 (45.4%) of 393 completed trials had published results; 48 trials were registered by known stem cell tourism clinics, none of which reported results. Completed non-industry-sponsored trials initially published more rapidly, but differences with industry-sponsored trials decreased over time. Most publications reported safety, and 67.3% (mainly early-stage trials) reported

SUBMITTER: Fung M 

PROVIDER: S-EPMC5425617 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature