Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.

ABSTRACT: The striking rise of obesity-related metabolic disorders has focused attention on adipocytes as critical mediators of disease phenotypes. To better understand the role played by excess adipose in metabolic dysfunction it is crucial to decipher the transcriptional underpinnings of the low-grade adipose inflammation characteristic of diseases such as type 2 diabetes. Through employing a comparative transcriptomics approach, we identified IRF1 as differentially regulated between primary and in vitro-derived genetically matched adipocytes. This suggests a role as a mediator of adipocyte inflammatory phenotypes, similar to its function in other tissues. Utilizing adipose-derived mesenchymal progenitors we subsequently demonstrated that expression of IRF1 in adipocytes indeed contributes to upre

SUBMITTER: Friesen M 

PROVIDER: S-EPMC5425619 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature