Protein-protein interactions in a crowded environment.

ABSTRACT: Protein-protein interactions are important in many essential biological functions, such as transcription, translation, and signal transduction. Much progress has been made in understanding protein-protein association in dilute solution via experimentation and simulation. Cells, however, contain various macromolecules, such as DNA, RNA, proteins, among many others, and a myriad of non-specific interactions (usually weak) are present between these cellular constituents. In this review article, we describe the important developments in recent years that have furthered our understanding and even allowed prediction of the consequences of macromolecular crowding on protein-protein interactions. We outline the development of our crowding theory that can predict the change in binding free energy d

SUBMITTER: Bhattacharya A 

PROVIDER: S-EPMC5425720 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature