Association Between a Polymorphism in CASP3 and CASP9 Genes and Ischemic Stroke.

ABSTRACT:

Objective

To investigate whether the polymorphisms of CASP3 gene (rs4647602, intron A/C and rs1049216, UTR C/T) and CASP9 gene (rs1052576, Gln/Arg G/A and rs1052571, Ser/Val T/C) were associated with the development, and clinical severity of ischemic stroke and functional consequences after stroke.

Methods

Genomic DNA from 121 ischemic stroke patients and 201 healthy control subjects were extracted, and polymerase chain reaction products were sequenced. To investigate the association of polymorphisms and the development, and National Institutes of Health Stroke Scale (K-NIHSS), logistic regression models were analyzed.

Results

Polymorphism of the untranslational region of CASP3 (rs1049216, UTR C/T) has been associated with the development of ische

SUBMITTER: Lee BY 

PROVIDER: S-EPMC5426270 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature