Running wheel training does not change neurogenesis levels or alter working memory tasks in adult rats.

ABSTRACT:

Background

Exercise can change cellular structure and connectivity (neurogenesis or synaptogenesis), causing alterations in both behavior and working memory. The aim of this study was to evaluate the effect of exercise on working memory and hippocampal neurogenesis in adult male Wistar rats using a T-maze test.

Methods

An experimental design with two groups was developed: the experimental group (n = 12) was subject to a forced exercise program for five days, whereas the control group (n = 9) stayed in the home cage. Six to eight weeks after training, the rats' working memory was evaluated in a T-maze test and four choice days were analyzed, taking into account alternation as a working memory indicator. Hippocampal neurogenesis was evaluated by means of immunohi

SUBMITTER: Acevedo-Triana CA 

PROVIDER: S-EPMC5426350 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature