Interference Between Respiratory Syncytial Virus and Human Rhinovirus Infection in Infancy.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) and human rhinovirus (HRV) are the most common viruses associated with acute respiratory tract infections in infancy. Viral interference is important in understanding respiratory viral circulation and the impact of vaccines.

Methods

To study viral interference, we evaluated cases of RSV and HRV codetection by polymerase chain reaction in 2 prospective birth cohort studies (the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure [INSPIRE] study and the Tennessee Children's Respiratory Initiative [TCRI]) and a double-blinded, randomized, controlled trial (MAKI), using adjusted multivariable regression analyses.

Results

Among 3263 respiratory tract samples, 24.5% (798) and 37.3% (1216) were RSV and

SUBMITTER: Achten NB 

PROVIDER: S-EPMC5426371 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature