A new H₂S-specific near-infrared fluorescence-enhanced probe that can visualize the H₂S level in colorectal cancer cells in mice.

ABSTRACT: Near-infrared (NIR) fluorescence-based sensors capable of selective detection of H₂S in vivo would be useful tools to understand the mechanisms of diseases. A new NIR fluorescence probe 1 was developed for the detection of endogenous H₂S in colorectal cancer cells in mice. 1 displayed an 87-fold fluorescence enhancement at 796 nm (with excitation at 730 nm) when reacted with H₂S in a buffer (pH 7.4). 1 was water-soluble, cell-membrane-permeable, had low cytotoxicity and high selectivity and sensitivity for H₂S. The properties of 1 enable its use in monitoring endogenous H₂S in living cells, tissues, and mice. The bioimaging results indicated that (1) d-Cys could induce endogenous H₂S produc

SUBMITTER: Zhang K 

PROVIDER: S-EPMC5426460 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature