Intervention effects of five cations and their correction on hemolytic activity of tentacle extract from the jellyfish Cyanea capillata.

ABSTRACT: Cations have generally been reported to prevent jellyfish venom-induced hemolysis through multiple mechanisms by spectrophotometry. Little attention has been paid to the potential interaction between cations and hemoglobin, potentially influencing the antagonistic effect of cations. Here, we explored the effects of five reported cations, La³⁺, Mn²⁺, Zn²⁺, Cu²⁺ and Fe²⁺, on a hemolytic test system and the absorbance of hemoglobin, which was further used to measure their effects on the hemolysis of tentacle extract (TE) from the jellyfish Cyanea capillata. All the cations displayed significant dose-dependent inhibitory effects on TE-induced hemolysis with various dissociation equilibrium constant (K_d) values as f

SUBMITTER: Zhang H 

PROVIDER: S-EPMC5426461 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature