Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients.

ABSTRACT: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular heterogeneity, we longitudinally profiled the blood transcriptome of 158 pediatric patients. Using mixed models accounting for repeated measurements, demographics, treatment, disease activity (DA), and nephritis class, we confirmed a prevalent IFN signature and identified a plasmablast signature as the most robust biomarker of DA. We detected gradual enrichment of neutrophil transcripts during progression to active nephritis and distinct signatures in response to treatment in different nephritis subclasses. Importantly, personalized immunomonitoring uncovered individual correlates of disease activity that enabled

SUBMITTER: Banchereau R 

PROVIDER: S-EPMC5426482 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature