The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats.

ABSTRACT: This study was to evaluate the age-dependent effects of caffeine exposure on the long bones and reproductive organs using male rats. A total of 15 immature male rats and 15 young adult male rats were allocated randomly to three groups: a control group and two groups fed caffeine with 120 and 180 mg/kg/day for 4 weeks. Exposure to caffeine at either dose significantly reduced body weight gain; a proportional reduction in muscle and fat mass in immature animals, whereas a selective reduction in fat mass with relatively preserved muscle mass in young adult animals. The long bones of immature rats exposed to caffeine were significantly shorter and lighter than those of control animals along with decreased bone minerals. However, there was no difference in the length or weight of the long bones

SUBMITTER: Kwak Y 

PROVIDER: S-EPMC5426506 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature