Ontology highlight
ABSTRACT:
SUBMITTER: De Mattos-Arruda L
PROVIDER: S-EPMC5426516 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Nature communications 20151110
Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the genomic alterations present in tumours and has been used to monitor tumour progression and response to treatments. However, patients with brain tumours do not present with or present with low amounts of ctDNA in plasma precluding the genomic characterization of brain cancer through plasma ctDNA. Here we show that ctDNA derived from central nervous system tumours is more abundantly present in the cerebrospi ...[more]