Maternal plasma PUFA concentrations during pregnancy and childhood adiposity: the Generation R Study.

ABSTRACT:

Background

Maternal polyunsaturated fatty acid (PUFA) concentrations during pregnancy may have persistent effects on growth and adiposity in the offspring. A suboptimal maternal diet during pregnancy might lead to fetal cardiometabolic adaptations with persistent consequences in the offspring.

Objective

We examined the associations of maternal PUFA concentrations during pregnancy with childhood general and abdominal fat-distribution measures.

Design

In a population-based, prospective cohort study of 4830 mothers and their children, we measured maternal second-trimester plasma n-3 (ω-3) and n-6 (ω-6) PUFA concentrations. At the median age of 6.0 y (95% range: 5.6, 7.9 y), we measured childhood body mass index (BMI), the fat mass percentage, and the android:gynoid fat r

SUBMITTER: Vidakovic AJ 

PROVIDER: S-EPMC5426536 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature