Densin-180 Controls the Trafficking and Signaling of L-Type Voltage-Gated Ca_v1.2 Ca²⁺ Channels at Excitatory Synapses.

ABSTRACT: Voltage-gated Ca_v1.2 and Ca_v1.3 (L-type) Ca²⁺ channels regulate neuronal excitability, synaptic plasticity, and learning and memory. Densin-180 (densin) is an excitatory synaptic protein that promotes Ca²⁺-dependent facilitation of voltage-gated Ca_v1.3 Ca²⁺ channels in transfected cells. Mice lacking densin (densin KO) exhibit defects in synaptic plasticity, spatial memory, and increased anxiety-related behaviors-phenotypes that more closely match those in mice lacking Ca_v1.2 than Ca_v1.3. Therefore, we investigated the functional impact of densin on Ca_v1.2. We report that densin is an essential regulator of Ca_v1.2 in neurons, but has distinct modulatory effects compared with its re

SUBMITTER: Wang S 

PROVIDER: S-EPMC5426563 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature