Apathy, but not depression, is associated with executive dysfunction in cerebral small vessel disease.

ABSTRACT:

Objective

To determine the prevalence of apathy and depression in cerebral small vessel disease (SVD), and the relationships between both apathy and depression with cognition. To examine whether apathy is specifically related to impairment in executive functioning and processing speed.

Methods

196 patients with a clinical lacunar stroke and an anatomically corresponding lacunar infarct on MRI were compared to 300 stroke-free controls. Apathy and depression were measured using the Geriatric Depression Scale, and cognitive functioning was assessed using an SVD cognitive screening tool, the Brief Memory and Executive Test, which measures executive functioning/processing speed and memory/orientation. Path analysis and binary logistic regression were used to assess the relation b

SUBMITTER: Lohner V 

PROVIDER: S-EPMC5426624 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature