Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure.

ABSTRACT:

Background

Although Plasmodium vivax contributes to almost half of all malaria cases outside Africa, it has been relatively neglected compared to the more deadly P. falciparum. It is known that P. vivax populations possess high genetic diversity, differing geographically potentially due to different vector species, host genetics and environmental factors.

Results

We analysed the high-quality genomic data for 46 P. vivax isolates spanning 10 countries across 4 continents. Using population genetic methods we identified hotspots of selection pressure, including the previously reported MRP1 and DHPS genes, both putative drug resistance loci. Extra copies and deletions in the promoter region of another drug resistance candidate, MDR1 gene, and duplications in the Duffy binding pr

SUBMITTER: Diez Benavente E 

PROVIDER: S-EPMC5426636 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature