Left ventricular functional, structural and energetic effects of normal aging: Comparison with hypertension.

ABSTRACT:

Objectives

Both aging and hypertension are significant risk factors for heart failure in the elderly. The purpose of this study was to determine how aging, with and without hypertension, affects left ventricular function.

Methods

Cross-sectional study of magnetic resonance imaging and 31P spectroscopy-based measurements of left ventricular structure, global function, strains, pulse wave velocity, high energy phosphate metabolism in 48 normal subjects and 40 treated hypertensive patients (though no other cardiovascular disease or diabetes) stratified into 3 age deciles from 50-79 years.

Results

Normal aging was associated with significant increases in systolic blood pressure, vascular stiffness, torsion, and impaired diastolic function (all P<0.05). Age-matched hyperte

SUBMITTER: Parikh JD 

PROVIDER: S-EPMC5426746 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature