Serum folate concentration and the incidence of lung cancer.

ABSTRACT:

Background

Lung cancer is a leading cause of cancer-related mortality globally. Folate helps to maintain DNA integrity and to regulate gene expression. Serum folate levels may affect the risk of several cancers, including lung cancer. In this study we evaluated the association between serum folate concentration and variations in genes involved in folate metabolism with lung cancer incidence in Poland.

Methods

The study included 366 lung cancer patients and 366 control subjects. We measured serum folate concentration and genotyped six variants in MTHFR, MTR and MTRR genes. The odds ratios of being diagnosed with lung cancer were calculated using conditional univariable and multivariable logistic regression with respect to folate level and genotypes.

Results

The mean se

SUBMITTER: Durda K 

PROVIDER: S-EPMC5426769 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature