Updated results from GEST study: a randomized, three-arm phase III study for advanced pancreatic cancer.

ABSTRACT:

Purpose

The GEST study showed non-inferiority of S-1 but not superiority of gemcitabine plus S-1 (GS) to gemcitabine alone for overall survival with the data by the cut-off date of 31st July in 2010 for chemo-naïve patients with advanced pancreatic cancer. We considered it important to determine whether S-1 maintains non-inferiority after a long-term follow-up in the GEST study and to obtain a firm positive conclusion. In addition, it may be an interesting challenge to explore the efficacious profile of GS in the long-term follow-up study. Using the data from the follow-up period, background and efficacy in patients from Taiwan and Japan, as well as the rates of tumor shrinkage in locally advanced and metastatic patients (Waterfall plot) were also analyzed.

Methods

The resul

SUBMITTER: Okusaka T 

PROVIDER: S-EPMC5427167 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature